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Reduced blood flow and impaired neurovascular coupling are well-known features of glaucoma, the main cause of non-curable blindness, affecting 80 million people worldwide in 2020. The mechanisms behind these abnormalities are now known, thanks to new research by a team led by Adriana Di Polo, professor of neuroscience and ophthalmology at Université de Montréal. The findings by Luis Alarcon-Martinez and Yukihiro Shiga, both post-doctoral fellows in Di Polo’s laboratory and co-authors of the study, reveal that nanotubes connecting pericytes are damaged in glaucoma leading to neurovascular failures.


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Phil Zeitler, MD, PhD, has been treating kids with type 2 diabetes for more than 20 years. He and a team of researchers published a paper in the TODAY2 Study in the New England Journal of Medicine on the long-term complications of type 2 diabetes. (TODAY stands for Treatment Options for type 2 Diabetes in Adolescents and Youth). The first phase of the study took place from 2004 -- 2011; phase two from 2011 -- 2020. Both studies involved more than 550 participants from across the country.


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New insight on how people with retinal degenerative disease can maintain their night vision for a relatively long period of time has been published today in the open-access eLife journal. The study suggests that second-order neurons in the retina, which relay visual signals to the retinal ganglion cells that project into the brain, maintain their activity in response to photoreceptor degeneration to resist visual decline -- a process known as homeostatic plasticity.


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Eyes hold clues for treating severe autism more effectively Vocabulary tests for individuals with the severest forms of autism spectrum disorder, or ASD, are notoriously inaccurate. They commonly ask the test-taker to point to an illustration after hearing a spoken word, measuring the ability to understand and perform a task as much as word knowledge.


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